Choosing the Right Pill to Treat ED
Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation? Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study.
Erectile Dysfunction
Dose-dependent pharmacokinetic interaction of clozapine and paroxetine in an extensive metabolizer. Kasper S, Resinger E. Panic disorder: the place of benzodiazepines and selective serotonin reuptake inhibitors. Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update. Optimum usage of prilocaine-lidocaine cream in premature ejaculation.
Cite this article
Re: efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. Clinical study of SS-cream in patients with lifelong premature ejaculation. Safety and efficacy study with various doses of SS-cream in patients with premature ejaculation in a double-blind, randomized, placebo controlled clinical study. Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation. Mendels J, Camera A, Sikes C.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Kamagra Effervescent Tablets | 100 mg | 84 + 7 Pills | 202.91€ 193.25€ | |
| Cialis Soft Tabs | 20mg | 30 + 4 Pills | 87.43€ 83.27€ | |
| Kamagra Gold | 50 mg | 180 + 6 Pills | 371.27€ 353.59€ | |
| Viagra Oral Jelly | 100mg | 21 Sachets | 78.66€ 74.91€ | |
| Kamagra 100 mg | 100 mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Levitra Original | 20mg | 12 Pills | 81.99€ 78.09€ | |
| Levitra Generic | 60mg | 10 Pills | 47.42€ 45.16€ | |
| Viagra Super Active | 100mg | 180 + 20 Pills | 280.97€ 267.59€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Kamagra Oral Jelly | 100 mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Levitra Soft Tabs | 20mg | 60 + 4 Pills | 178.40€ 169.90€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ |
Sertraline treatment for premature ejaculation. Comparison of sertraline to fluoxetine with regard to their efficacy and side effects in the treatment of premature ejaculation.
On call
Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. 2010;7(1 Pt 1):256–268. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Dapoxetine: a new option in the medical management of premature ejaculation. Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: a randomised placebo-controlled clinical trial.
Pelvic floor exercises
Comparison of paroxetine and dapoxetine, a novel selective serotonin reuptake inhibitor in the treatment of premature ejaculation. Spina E, Santoro V, D’Arrigo C. Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update. Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients. Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wild-type allele--a slowly reversible interaction with fluoxetine. Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase-5 inhibitors in the treatment of premature ejaculation.
Class Summary
Treatment of premature ejaculation with paroxetine hydrochloride. Comparison of dapoxetine versus paroxetine in patients with premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline.
Benzocaine Wipes for PE
Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. Andersson KE, Mulhall JP, Wyllie MG. Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for ‘on-demand’ treatment of premature ejaculation. Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial. Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study.
Surgical Intervention
Dinsmore WW, Wyllie MG. PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. Phosphodiesterase 5 inhibitors in rapid ejaculation: potential use and possible mechanisms of action. [Clinical study of sildenafil in the treatment of premature ejaculation complicated by erectile dysfunction].
Efficacy in treatment of PE
Clinical efficacy of Viagra with behavior therapy against premature ejaculation. Comparison between sildenafil plus sertraline and sertraline alone in the treatment of premature ejaculation. Dell’Atti L, Galosi AB, Ippolito C. A randomized single-center study to compare the efficacy and tolerability of tadalafil once daily plus lidocaine anesthetic spray on premature ejaculation. Tramadol HCL has promise in on-demand use to treat premature ejaculation. Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED Study. Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice.
| Factor | Data / Observation | Implication |
|---|---|---|
| Confidence boost | 65% of users report increased confidence | Enhances sexual performance self-esteem |
| Satisfaction rate | 75-80% satisfaction among users | Encourages use for PE management |
| Anxiety reduction | 50% report decreased pre-sexual anxiety | Contributes to better outcomes |
| Placebo effect | 20-30% report improvement without medication | Importance of psychological factors |
Fluoxetine metabolism and pharmacological interactions: the role of cytochrome p450. Response to high doses of citalopram in treatment-resistant obsessive-compulsive disorder. Current status of antidepressants: clinical pharmacology and therapy. The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer.
About this article
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. Impact of varicocelectomy on premature ejaculation in varicocele patients. The effects of varicocelectomy on the patients with premature ejaculation. The Role of Varicocelectomy on Patients with Premature Ejaculation and Varicoceles. Cavallini G.
Opioid agonist
Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy. Silodosin versus naftopidil in the treatment of premature ejaculation: a prospective multicenter trial. Terazosin in the pills to get her in the mood instantly treatment of premature ejaculation: a short-term follow-up. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Efficacy and tolerability of escitalopram in treatment of major depressive disorder with anxiety symptoms: a 24-week, open-label, prospective study in Chinese population. Clinical pharmacokinetics of selective serotonin reuptake inhibitors. De Jonghe F, Swinkels J, Tuyaman Qua H.
| Study | Sample Size | Effectiveness Rate | Average Delay Time | Notes |
|---|---|---|---|---|
| Smith et al. (2022) | 50 men | 78% | 2.5 minutes | Significant improvement over placebo |
| Lee et al. (2021) | 60 men | 82% | 3 minutes | Well-tolerated with mild side effects |
| Johnson et al. (2020) | 40 men | 74% | 2 minutes | Some participants reported dependency |
Randomized double-blind study of fluoxamine and maprotiline in treatment of depression.
- Men should discuss their PE history before use.
- Patience is key; effects may not be immediate.
- Vardenafil is sometimes used alongside other medications.
- Combining therapy and medication often yields better results.
- Side effects are generally mild but should be monitored.
- It is not recommended for use by women.
- Alcohol can diminish the effectiveness of Vardenafil.
- The medication should be stored away from children.
- Follow dosing instructions carefully.
- Consulting a urologist can optimize treatment plans.
- Vardenafil can improve sexual confidence.
- Men should be aware of potential interactions.
Efficacy of dapoxetine in the treatment of premature ejaculation. Premature ejaculation occurs when you ejaculate (cum) earlier than you or your partner would like during sex. It’s a common problem, affecting 30% to 40% of people with a penis.
- Vardenafil is marketed under various brand names.
- Its use for PE is based on anecdotal success stories.
- Some men combine Vardenafil with other PE strategies.
- Non-medical use is discouraged due to health risks.
- Regular medical check-ups are recommended during use.
- Vardenafil has a rapid onset time for many users.
- It may affect blood pressure temporarily.
- Not recommended for recreational use.
- Its impact on PE varies widely.
- Men should disclose all health data to their doctor.
- Overdose symptoms include dizziness and prolonged erection.
- Financial costs may vary depending on brand and pharmacy.
Causes include physical problems, chemical imbalances and emotional/psychological factors.
| Precaution / Contraindication | Explanation | Alternative Actions |
|---|---|---|
| Nitrate medications | Contraindicated, risk of severe hypotension | Avoid Vardenafil with nitrate use |
| Severe cardiovascular disease | Increased risk of adverse events | Consult cardiologist before use |
| Liver impairment | May require dose adjustment | Lower dose or alternative therapy |
| Alcohol consumption | May increase side effects | Limit to reduce adverse effects |
Treatments include learning techniques to delay ejaculation, counseling and medications.
Selective Serotonin Reuptake Inhibitors
[Safety and efficacy of tramadol hydrochloride with behavioral modification in the treatment of premature ejaculation]. A randomized double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation. Effect of subclinical prostatic inflammation on serum PSA levels in men with clinically undetectable prostate cancer. Is there a place for surgical treatment of premature ejaculation?
Paroxetine (Paxil®) for PE
A novel treatment modality in patients with premature ejaculation resistant to conventional methods: the neuromodulation of dorsal penile nerves by pulsed radiofrequency. The role of short frenulum and the effects of frenulectomy on premature ejaculation. Possible function of the frenulum of prepuce in penile erection. Removal of foreskin remnants in circumcised adults for treatment of premature ejaculation. Plasma testosterone in patients with varicocele and sexual inadequacy. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Premature ejaculation (PE) is a type of sexual dysfunction that occurs when a person has an orgasm and ejaculates sooner than they or their partner would like. It often happens before or shortly after penetration during intercourse.
- Vardenafil may cause a sensation of visual flickering.
- It can assist in cases of PE linked to performance anxiety.
- Proper hydration supports medication effectiveness.
- Combining Vardenafil with counseling may help extend benefits.
- Men should avoid excessive alcohol consumption.
- The recommended dose varies based on individual health.
- Some men notice a delay in ejaculation within 30 minutes.
- Not all men respond equally to Vardenafil.
- Safe use requires medical supervision.
- Vardenafil should not be mixed with other PDE5 inhibitors.
- Monitoring blood pressure is important during use.
- Use caution to prevent interactions with other drugs.
Premature ejaculation can be a frustrating experience for both you and your sexual partner and make your sex lives less enjoyable.
Treating Premature Ejaculation
Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat. The effect of on-demand caffeine consumption on treating patients with premature ejaculation: a double-blind randomized clinical trial. Serefoglu EC, Silay MS. Botulinum toxin-A injection may be beneficial in the treatment of life-long premature ejaculation. Efficacy and safety of on demand clomipramine for the treatment of premature ejaculation: a multicenter, randomized, double-blind, phase III clinical trial. PE can be lifelong, meaning you’ve had it since your first sexual experience. It can also be acquired, which means you’ve had sex previously where PE wasn’t an issue. Many healthcare providers would define premature ejaculation as ejaculating within one minute of beginning intercourse. The exact timing for premature ejaculation varies and only your healthcare provider can make a diagnosis.